Published papers on telepathology projects

Document Type : Articles

Authors

Abstract

Introduction: Although many studies have been conducted in the telepathology field in recent years, a systematic review that examines studies in a comparative manner has not yet been undertaken. This paper aims to review the published papers on telepathology projects and compare them in several aspects such as telepathology method,telecommunication method, clinical outcome, etc.Methods: PubMed database was used to find the studies published in the past ten years (2004–2014). Data were extracted from these studies based on the following items: country, national (in country) or international (between countries), frozen section or slide, body part, type of camera used, telecommunication method, telepathology method, clinical outcome, cost evaluation, satisfaction evaluation and the description of consultation providers and receivers.Results: Results showed that most of the studies were performed in developed countries on a national level, on slide and on a specific body part. In most studies, a Nikon camera was used to take images. Online methods were the most used telecommunication method in the studies, while store and forward was the most used telepathology method. Clinical outcome of many studies showed that telepathology is a reliable and accurate method for consultation. More than half of the studies considered the cost, and most of them showed that a telepathology system is cost effective. Few studies evaluated satisfaction of the participants. In most studies, the telepathology project was undertaken between pathologists.Conclusion: Although there is enough evidence to suggest that telepathology is an effective way of consultation between pathologists, there are still some areas that should be addressed and for which there is a lack of convincing evidence. For example, pathologist satisfaction, cost evaluation, legal issues and ethical issues still need to be addressed. Keywords:Telepathology,Systematic review, Teleconsultation

  1. References
  2. Frierson HF, Jr., Galgano MT. Frozen-section diagnosis by wireless telepathology and ultra portable computer: use in pathology resident/faculty consultation. Hum Pathol. 2007 Sep;38(9):1330-4.
  3. Weinstein RS. Prospects for telepathology. Human pathology. 1986 May;17(5):433-4.
  4. Della Mea V. 25 years of telepathology research: a bibliometric analysis. Diagnostic pathology. 2011;6 Suppl 1:S26.
  5. Weinstein RS. Static image telepathology in perspective. Human pathology. 1996 Feb;27(2):99-101.
  6. Weinstein RS, Descour MR, Liang C, Bhattacharyya AK, Graham AR, Davis JR, et al. Telepathology overview: from concept to implementation. Human pathology. 2001 Dec;32(12):1283-99.
  7. Zhou J, Hogarth MA, Walters RF, Green R, Nesbitt TS. Hybrid system for telepathology. Human pathology. 2000 Jul;31(7):829-33.
  8. Furness P. A randomized controlled trial of the diagnostic accuracy of internet-based telepathology compared with conventional microscopy. Histopathology. 2007 Jan;50(2):266-73.
  9. Al-Janabi S, Huisman A, Nikkels PG, ten Kate FJ, van Diest PJ. Whole slide images for primary diagnostics of paediatric pathology specimens: a feasibility study. J Clin Pathol. 2013 Mar;66(3):218-23.
  10. Speiser JJ, Hughes I, Mehta V, Wojcik EM, Hutchens KA. Mobile Teledermatopathology: Using a Tablet PC as a Novel and Cost-Efficient Method to Remotely Diagnose Dermatopathology Cases. Am J Dermatopathol. 2014 Jan;36(1):54-7.
  11. Bahaadinbeigy K, Yogesan K, Wootton R. MEDLINE versus EMBASE and CINAHL for telemedicine searches. Telemedicine journal and e-health : the official journal of the American Telemedicine Association. 2010 Oct;16(8):916-9.
  12. Brauchli K, Jagilly R, Oberli H, Kunze KD, Phillips G, Hurwitz N, et al. Telepathology on the Solomon Islands--two years’ experience with a hybrid Web- and email-based telepathology system. J Telemed Telecare. 2004;10 Suppl 1:14-7.
  13. Ferrara G, Argenziano G, Cerroni L, Cusano F, Di Blasi A, Urso C, et al. A pilot study of a combined dermoscopic-pathological approach to the telediagnosis of melanocytic skin neoplasms. J Telemed Telecare. 2004;10(1):34-8.
  14. Lanschuetzer CM, Pohla-Gubo G, Schafleitner B, Hametner R, Hashimoto T, Salmhofer W, et al. Telepathology using immunofluorescence/immunoperoxidase microscopy. J Telemed Telecare. 2004;10(1):39-43.
  15. Mireskandari M, Kayser G, Hufnagl P, Schrader T, Kayser K. Teleconsultation in diagnostic pathology: experience from Iran and Germany with the use of two European telepathology servers. J Telemed Telecare. 2004;10(2):99-103.
  16. Nordrum I, Johansen M, Amin A, Isaksen V, Ludvigsen JA. Diagnostic accuracy of second-opinion diagnoses based on still images. Hum Pathol. 2004 Jan;35(1):129-35.
  17. Burthem J, Brereton M, Ardern J, Hickman L, Seal L, Serrant A, et al. The use of digital ‘virtual slides’ in the quality assessment of haematological morphology: results of a pilot exercise involving UK NEQAS(H) participants. Br J Haematol. 2005 Jul;130(2):293-6.
  18. Hitchcock CL, Hitchcock LE. Three years of experience with routine use of telepathology in assessment of excisional and aspirate biopsies of breast lesions. Croat Med J. 2005 Jun;46(3):449-57.
  19. Johnston DJ, Costello SP, Dervan PA, O’Shea DG. Development and preliminary evaluation of the VPS ReplaySuite: a virtual double-headed microscope for pathology. BMC Med Inform Decis Mak. 2005;5:10.
  20. Abdirad A, Sarrafpour B, Ghaderi-Sohi S. Static telepathology in cancer institute of Tehran university: report of the first academic experience in Iran. Diagn Pathol. 2006;1:33.
  21. Hutarew G, Schlicker HU, Idriceanu C, Strasser F, Dietze O. Four years experience with teleneuropathology. J Telemed Telecare. 2006;12(8):387-91.
  22. Jialdasani R, Desai S, Gupta M, Kothari A, Deshpande R, Shet T, et al. An analysis of 46 static telecytology cases over a period of two years. J Telemed Telecare. 2006;12(6):311-4.22.
  23. Leinweber B, Massone C, Kodama K, Kaddu S, Cerroni L, Haas J, et al. Teledermatopathology: a controlled study about diagnostic validity and technical requirements for digital transmission. Am J Dermatopathol. 2006 Oct;28(5):413-6.
  24. Odze RD, Tomaszewski JE, Furth EE, Feldman MD, Diallo R, Poremba C, et al. Variability in the diagnosis of dysplasia in ulcerative colitis by dynamic telepathology. Oncol Rep. 2006 Nov;16(5):1123-9.
  25. Horbinski C, Fine JL, Medina-Flores R, Yagi Y, Wiley CA. Telepathology for intraoperative neuropathologic consultations at an academic medical center: a 5-year report. J Neuropathol Exp Neurol. 2007 Aug;66(8):750-9.
  26. Li X, Liu J, Xu H, Gong E, McNutt MA, Li F, et al. A feasibility study of virtual slides in surgical pathology in China. Hum Pathol. 2007 Dec;38(12):1842-8.
  27. Massone C, Soyer HP, Lozzi GP, Di Stefani A, Leinweber B, Gabler G, et al. Feasibility and diagnostic agreement in teledermatopathology using a virtual slide system. Hum Pathol. 2007 Apr;38(4):546-54.
  28. McKenna JK, Florell SR. Cost-effective dynamic telepathology in the Mohs surgery laboratory utilizing iChat AV videoconferencing software. Dermatol Surg. 2007 Jan;33(1):62-8; discussion 8.
  29. Banach L, Stepien A, Schneider J, Wichrzycka-Lancaster E. Dynamic active telepathology over National Health Laboratory service network, South Africa: feasibility study using Nikon Coolscope. Diagn Pathol. 2008;3 Suppl 1:S3.
  30. Eichhorn JH, Buckner L, Buckner SB, Beech DP, Harris KA, McClure DJ, et al. Internet-based gynecologic telecytology with remote automated image selection: results of a first-phase developmental trial. Am J Clin Pathol. 2008 May;129(5):686-96.
  31. Kerr SE, Bellizzi AM, Stelow EB, Frierson HF, Jr., Policarpio-Nicolas ML. Initial assessment of fine-needle aspiration specimens by telepathology: validation for use in pathology resident-faculty consultations. Am J Clin Pathol. 2008 Sep;130(3):409-13.
  32. Li X, Gong E, McNutt MA, Liu J, Li F, Li T, et al. Assessment of diagnostic accuracy and feasibility of dynamic telepathology in China. Hum Pathol. 2008 Feb;39(2):236-42.
  33. Slodkowska J, Chyczewski L, Wojciechowski M. Virtual slides: application in pulmonary pathology consultations. Folia Histochem Cytobiol. 2008;46(1):121-4.
  34. Tsuchihashi Y, Takamatsu T, Hashimoto Y, Takashima T, Nakano K, Fujita S. Use of virtual slide system for quick frozen intra-operative telepathology diagnosis in Kyoto, Japan. Diagn Pathol. 2008;3 Suppl 1:S6.
  35. Bellina L, Missoni E. Mobile cell-phones (M-phones) in telemicroscopy: increasing connectivity of isolated laboratories. Diagn Pathol. 2009;4:19.
  36. Dunn BE, Choi H, Recla DL, Kerr SE, Wagenman BL. Robotic surgical telepathology between the Iron Mountain and Milwaukee Department of Veterans Affairs Medical Centers: a 12-year experience. Hum Pathol. 2009 Aug;40(8):1092-9.
  37. Evans AJ, Chetty R, Clarke BA, Croul S, Ghazarian DM, Kiehl TR, et al. Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience. Hum Pathol. 2009 Aug;40(8):1070-81.
  38. Graham AR, Bhattacharyya AK, Scott KM, Lian F, Grasso LL, Richter LC, et al. Virtual slide telepathology for an academic teaching hospital surgical pathology quality assurance program. Hum Pathol. 2009 Aug;40(8):1129-36.
  39. Horbinski C, Wiley CA. Comparison of telepathology systems in neuropathological intraoperative consultations. Neuropathology. 2009 Dec;29(6):655-63.
  40. Kldiashvili E, Schrader T. Implementation of telepathology in the republic of georgia. Telemed J E Health. 2009 Jun;15(5):479-83.
  41. Lopez AM, Graham AR, Barker GP, Richter LC, Krupinski EA, Lian F, et al. Virtual slide telepathology enables an innovative telehealth rapid breast care clinic. Semin Diagn Pathol. 2009 Nov;26(4):177-86.
  42. Slodkowska J, Pankowski J, Siemiatkowska K, Chyczewski L. Use of the virtual slide and the dynamic real-time telepathology systems for a consultation and the frozen section intra-operative diagnosis in thoracic/pulmonary pathology. Folia Histochem Cytobiol. 2009;47(4):679-84.
  43. Wienert S, Beil M, Saeger K, Hufnagl P, Schrader T. Integration and acceleration of virtual microscopy as the key to successful implementation into the routine diagnostic process. Diagn Pathol. 2009;4:3.
  44. Alsharif M, Carlo-Demovich J, Massey C, Madory JE, Lewin D, Medina AM, et al. Telecytopathology for immediate evaluation of fine-needle aspiration specimens. Cancer Cytopathol. 2010 Jun 25;118(3):119-26.
  45. Angelini A, Andersen CB, Bartoloni G, Black F, Bishop P, Doran H, et al. A web-based pilot study of inter-pathologist reproducibility using the ISHLT 2004 working formulation for biopsy diagnosis of cardiac allograft rejection: the European experience. J Heart Lung Transplant. 2011 Nov;30(11):1214-20.
  46. Georgoulakis J, Archondakis S, Panayiotides I, Anninos D, Skagias L, Stamataki M, et al. Study on the reproducibility of thyroid lesions telecytology diagnoses based upon digitized images. Diagn Cytopathol. 2011 Jul;39(7):495-9.
  47. Harnden P, Coleman D, Moss S, Kodikara S, Griffin NR, Melia J. Evaluation of the use of digital images for a national prostate core external quality assurance scheme. Histopathology. 2011 Oct;59(4):703-9.
  48. Intersimone D, Snoj V, Riosa F, Bortolotti N, Sverko S, Beltrami CA, et al. Transnational telepathology consultations using a basic digital microscope: experience in the Italy-Slovenjia INTERREG project “patient without borders”. Diagn Pathol. 2011;6 Suppl 1:S25.
  49. Jukic DM, Drogowski LM, Martina J, Parwani AV. Clinical examination and validation of primary diagnosis in anatomic pathology using whole slide digital images. Arch Pathol Lab Med. 2011 Mar;135(3):372-8.
  50. Khurana KK, Swati I, Kasturi R, Lambert R, Izquierdo R. Telecytopathology for rapid preliminary diagnosis of ultrasound-guided fine-needle aspiration of thyroid nodules. Telemed J E Health. 2011 Dec;17(10):763-7.
  51. Kldiashvili E, Schrader T. Reproducibility of telecytology diagnosis of cervical smears in a quality assurance program: the Georgian experience. Telemed J E Health. 2011 Sep;17(7):565-8.
  52. Nassar A, Cohen C, Agersborg SS, Zhou W, Lynch KA, Barker EA, et al. A multisite performance study comparing the reading of immunohistochemical slides on a computer monitor with conventional manual microscopy for estrogen and progesterone receptor analysis. Am J Clin Pathol. 2011 Mar;135(3):461-7.
  53. Pagni F, Bono F, Di Bella C, Faravelli A, Cappellini A. Virtual surgical pathology in underdeveloped countries: The Zambia Project. Arch Pathol Lab Med. 2011 Feb;135(2):215-9.
  54. Tsang MW, Kovarik CL. The role of dermatopathology in conjunction with teledermatology in resource-limited settings: lessons from the African Teledermatology Project. Int J Dermatol. 2011 Feb;50(2):150-6.
  55. Wamala D, Katamba A, Dworak O. Feasibility and diagnostic accuracy of Internet-based dynamic telepathology between Uganda and Germany. J Telemed Telecare. 2011;17(5):222-5.
  56. Wiley CA, Murdoch G, Parwani A, Cudahy T, Wilson D, Payner T, et al. Interinstitutional and interstate teleneuropathology. J Pathol Inform. 2011;2:21.
  57. Zembowicz A, Ahmad A, Lyle SR. A comprehensive analysis of a web-based dermatopathology second opinion consultation practice. Arch Pathol Lab Med. 2011 Mar;135(3):379-83.
  58. Al-Janabi S, Huisman A, Vink A, Leguit RJ, Offerhaus GJ, Ten Kate FJ, et al. Whole slide images for primary diagnostics in dermatopathology: a feasibility study. J Clin Pathol. 2012 Feb;65(2):152-8.
  59. Gifford AJ, Colebatch AJ, Litkouhi S, Hersch F, Warzecha W, Snook K, et al. Remote frozen section examination of breast sentinel lymph nodes by telepathology. ANZ J Surg. 2012 Nov;82(11):803-8.
  60. Gimbel DC, Sohani AR, Prasad Busarla SV, Kirimi JM, Sayed S, Okiro P, et al. A static-image telepathology system for dermatopathology consultation in East Africa: the Massachusetts General Hospital Experience. J Am Acad Dermatol. 2012 Nov;67(5):997-1007.
  61. Kern I, Gabric S, Triller N, Pozek I. Telecytology for rapid assessment of cytological specimens. J Telemed Telecare. 2012 Mar;18(2):86-9.
  62. Khurana KK, Rong R, Wang D, Roy A. Dynamic telecytopathology for on-site preliminary diagnosis of endoscopic ultrasound-guided fine needle aspiration of pancreatic masses. J Telemed Telecare. 2012 Jul;18(5):253-9.
  63. Kumar N, Busarla SV, Sayed S, Kirimi JM, Okiro P, GakinyaSM, et al. Telecytology in East Africa: a feasibility study of forty cases using a static imaging system. J Telemed Telecare. 2012 Jan;18(1):7-12.
  64. Marotti JD, Johncox V, Ng D, Gonzalez JL, Padmanabhan V. Implementation of telecytology for immediate assessment of endoscopic ultrasound-guided fine-needle aspirations compared to conventional on-site evaluation: analysis of 240 consecutive cases. Acta Cytol. 2012;56(5):548-53.
  65. Nakayama I, Matsumura T, Kamataki A, Uzuki M, Saito K, Hobbs J, et al. Development of a teledermatopathology consultation system using virtual slides. Diagn Pathol. 2012;7:177.
  66. Sirintrapun SJ, Cimic A. Dynamic nonrobotic telemicroscopy via skype: A cost effective solution to teleconsultation. J Pathol Inform. 2012;3:28.
  67. Sohani AR, Sohani MA. Static digital telepathology: a model for diagnostic and educational support to pathologists in the developing world. Anal Cell Pathol (Amst). 2012;35(1):25-30.
  68. Izquierdo RE, Kasturi R, Khurana K, Hopkins R, Swati I. Feasibility of immediate assessment of fine needle aspirates of thyroid nodules by telecytopathology. Endocr Pract. 2013 Jan-Feb;19(1):14-8.
  69. Kadaba V, Ly T, Noor S, Chhut SV, Hinsch N, Stauch G, et al. A hybrid approach to telepathology in Cambodia. J Telemed Telecare. 2013 Dec;19(8):475-8.
  70. Mammas CS, Lazaris A, Geropoulos S, Saatsakis G, Lemonidou C, Patsouris E. Telepathology as a method to optimize quality in organ transplantation: a feasibility and reliability study of the virtual benching of pancreas graft. Stud Health Technol Inform. 2013;190:273-5.
  71. Sawai T, Uzuki M, Miura Y, Kamataki A, Matsumura T, Saito K, et al. World’s first telepathology experiments employing WINDS ultra-high-speed internet satellite, nicknamed “KIZUNA”. J Pathol Inform. 2013;4:24.
  72. Desai S, Patil R, Chinoy R, Kothari A, Ghosh TK, Chavan M, et al. Experience with telepathology at a tertiary cancer centre and a rural cancer hospital. Natl Med J India. 2004 Jan-Feb;17(1):17-9.
  73. Desai S, Patil R, Kothari A, Shet T, Kane S, Borges A, et al. Static telepathology consultation service between Tata Memorial Centre, Mumbai and Nargis Dutt Memorial Charitable Hospital, Barshi, Solapur, Maharashtra: an analysis of the first 100 cases. Indian J Pathol Microbiol. 2004 Oct;47(4):480-5.
  74. Bhele S, Jialdasani R, Kothari A, Bhosale S, Desai S. Analysis of deferrals on static telepathology consultation service. Indian J Pathol Microbiol. 2007 Oct;50(4):749-53.
  75. Fronza CF, Fronza H, Jr. Telepathology: diagnostic aid, second medical opinion and validation of the diagnostic efficiency. AMIA Annu Symp Proc. 2007:958.
  76. Ayad E, Yagi Y. Virtual microscopy beyond the pyramids, applications of WSI in Cairo University for E-education & telepathology. Anal Cell Pathol (Amst). 2012;35(2):93-5.
  77. Goyal A, Jhala N, Gupta P. TeleCyP (Telecytopathology): real-time fine-needle aspiration interpretation. Acta Cytol. 2012;56(6):669-77.
  78. Santiago TC, Jenkins JJ, Pedrosa F, Billups C, Quintana Y, Ribeiro RC, et al. Improving the histopathologic diagnosis of pediatric malignancies in a low-resource setting by combining focused training and telepathology strategies. Pediatr Blood Cancer. 2012 Aug;59(2):221-5.